NClClNHNHK2CO3, triethylamine,NClNNHONH2OONH2OONHOOOONHOOONHOONClNNNH2NClNNNHNClNNOFF+N-methyl-2-pyrrolidinone135°C, 4h4,7-dichloroquinolinepiperazine11.NH4OAc,EtOH2. malonic acid, MeOH3. SOCl21. 45°C, 12h2. 60°C overnight, then reflux for 6 h3.r.t. overnight, then reflux for 2 h2Benzaldehyde1. (+)- L -tartaric acid, MeOH2. 1N aq. NaOH1. -20°C overnight2. r.t.3(BOC)2O, Na2CO3 ,THF/H2O0°C for 1h, then at 25°C for 2h4DIBAL-H , DCM<-70°C, 2h5NaBH(OAc)3, HOAc, DCM25℃, 5h6saturated HCl in MeOH65°C, 2h74,4-difluorocyclohexanecarboxylic acidEDCI, HOBt, DIPEA, DCM25°C, 4 h8Step oneStep TwoStep ThreeStep FourStep FiveStep SixStep SevenStep Eight